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1

Enteral insulin delivery by microspheres in 3 different formulations using Eudragit L100 and S100

Isao Morishita, Mariko Morishita, Kozo Takayama, Yoshiharu Machida, Tsuneji Nagai

Journal:

International Journal of Pharmaceutics

Année:

1993

Langue:

english

Fichier:

PDF, 565 KB

english, 1993

2

Optimization of the Granulation Process for Designing Tablets.

MIYAMOTO, Yousuke, RYU, Akio, SUGAWARA, Shinya, MIYAJIMA, Masaharu, MATSUI, Masayuki, TAKAYAMA, Kozo, NAGAI, Tsuneji

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Année:

1998

Fichier:

PDF, 1.05 MB

1998

3

Invasive micropapillary carcinoma of the breast with minimal regional lymph node metastasis regardless of the huge size: Report of a case

Takashi Akiyoshi, Takashi Nagaie, Masanori Tokunaga, Masaaki Tajima, Makoto Morita, Akio Nakatsuka, Satoshi Taga, Shigeki Wakiyama, Masahiko Ikebe, Kozo Nakanishi, Mitsunori Hashimoto, Taisuke Toyomas

Journal:

Année:

2003

Langue:

english

Fichier:

PDF, 1.30 MB

english, 2003

4

Simultaneous optimization for several characteristics concerning percutaneous absorption and skin damage of ketoprofen hydrogels containing d-limonene

Kozo Takayama, Tsuneji Nagai

Journal:

International Journal of Pharmaceutics

Année:

1991

Langue:

english

Fichier:

PDF, 1.30 MB

english, 1991

5

Elucidation of the mechanism of incorporation of insulin in controlled release systems based on complexation polymers

Mariko Morishita, Anthony M. Lowman, Kozo Takayama, Tsuneji Nagai, Nicholas A. Peppas

Journal:

Journal of Controlled Release

Année:

2002

Langue:

english

Fichier:

PDF, 117 KB

english, 2002

6

Proactive transplantation of human neural stem cells prevents degeneration of striatal neurons in a rat model of Huntington disease

Jae K Ryu, Jean Kim, Sung J Cho, Kozo Hatori, Astushi Nagai, Hyun B Choi, Min C Lee, James G McLarnon, Seung U Kim

Journal:

Neurobiology of Disease

Année:

2004

Langue:

english

Fichier:

PDF, 614 KB

english, 2004

7

Characteristics of polyion complexes of chitosan with sodium alginate and sodium polyacrylate

Takahashi, Toshiya, Takayama, Kozo, Machida, Yoshiharu, Nagai, Tsuneji

Journal:

International Journal of Pharmaceutics

Année:

1990

Langue:

english

Fichier:

PDF, 537 KB

english, 1990

8

Evaluation of skin damage caused by percutaneous absorption enhancers using fractal analysis

Yasuko Obata, Takahiro Sesumi, Kozo Takayama, Koichi Isowa, Sharon Grosh, Steve Wick, Richard Sitz, Tsuneji Nagai

Journal:

Journal of Pharmaceutical Sciences

Année:

2000

Langue:

english

Fichier:

PDF, 158 KB

english, 2000

9

Enhanced enteral bioavailability of vancomycin using water-in-oil-in-water multiple emulsion incorporating highly purified unsaturated fatty acid

Masako Kajita, Mariko Morishita, Kozo Takayama, Yoshiyuki Chiba, Shinji Tokiwa, Tsuneji Nagai

Journal:

Journal of Pharmaceutical Sciences

Année:

2000

Langue:

english

Fichier:

PDF, 447 KB

english, 2000

10

Origin of hematopoietic progenitor cells after bone marrow transplantation: Analysis by means of a Y-chromosome specific DNA probe

Tomoko Nakatsumi, Dr. Shinji Nakao, Mamiko Ohtaguro, Tatsuya Chujo, Haruo Tsuchiya, Takeo Niki, Takao Mori, Tamotsu Matsuda, Shintaro Shiobara, Kozo Nagai

Journal:

American Journal of Hematology

Année:

1991

Langue:

english

Fichier:

PDF, 515 KB

english, 1991

11

Surgical treatment of aneurysm of the thoracic aorta under a temporary external by-pass shunt

Tadashi Inoue, Akira Shohtsu, Kozo Kawada, Izumi Nagai, Susumu Tanaka, Shigeyuki Takeuchi, Yasuhiro Sohma

Journal:

British Journal of Surgery

Année:

1973

Langue:

english

Fichier:

PDF, 353 KB

english, 1973

12

Fractalkine and fractalkine receptors in human neurons and glial cells

Kozo Hatori, Atsushi Nagai, Rochelle Heisel, Jae K. Ryu, Seung U. Kim

Journal:

Journal of Neuroscience Research

Année:

2002

Langue:

english

Fichier:

PDF, 971 KB

english, 2002

13

Regional intestinal absorption of FITC–dextran 4,400 with nanoparticles based on β-sitosterol β-d-glucoside in rats

Koji Nakamura, Kozo Takayama, Tsuneji Nagai, Yoshie Maitani

Journal:

Journal of Pharmaceutical Sciences

Année:

2003

Langue:

english

Fichier:

PDF, 122 KB

english, 2003

14

A new attempt to solve the scale-up problem for granulation using response surface methodology

Shigeo Ogawa, Toshihiko Kamijima, Yousuke Miyamoto, Masaharu Miyajima, Hiroshi Sato, Kozo Takayama, Tsuneji Nagai

Journal:

Journal of Pharmaceutical Sciences

Année:

1994

Langue:

english

Fichier:

PDF, 596 KB

english, 1994

15

Formulation optimization of indomethacin gels containing a combination of three kinds of cyclic monoterpenes as percutaneous penetration enhancers

Karin Kragh Levison, Kozo Takayama, Koichi Isowa, Keiichiro Okabe, Tsuneji Nagai

Journal:

Journal of Pharmaceutical Sciences

Année:

1994

Langue:

english

Fichier:

PDF, 855 KB

english, 1994

16

A new attempt to design erodible terpolymers using computer-optimization methodology

Kazumichi Imasaka, Kozo Takayama, Masaru Yoshida, Hideki Omichi, Tsuneji Nagai

Journal:

European Polymer Journal

Année:

1992

Langue:

english

Fichier:

PDF, 305 KB

english, 1992

17

Solubilization of cyclohexane in aqueous solutions of sodium a-alkyl alkanoates

Hiromichi Sagitani, Toshimitsu Suzuki, Masayoshi Nagai, Kozo Shinoda

Journal:

Journal of Colloid and Interface Science

Année:

1982

Langue:

english

Fichier:

PDF, 424 KB

english, 1982

18

Determination of timiperone in rat plasma by high-performance liquid chromatography with electrochemical detection

Toshiyuki Takayasu, Ikuhiro Kakubari, Akemi Fukamachi, Eiichi Mafune, Norio Takasugi, Kozo Takayama, Tsuneji Nagai

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Année:

1996

Langue:

english

Fichier:

PDF, 294 KB

english, 1996

19

The revised structure of viscosin, a peptide antibiotic

Minoru Hiramoto, Kozo Okada, Sotoo Nagai

Journal:

Tetrahedron Letters

Année:

1970

Langue:

english

Fichier:

PDF, 322 KB

english, 1970

20

Effect of synthesized cyclohexanol derivatives using l-menthol as a lead compound on the percutaneous absorption of ketoprofen

Yasuko Obata, Haruka Sato, Chao Jie Li, Kozo Takayama, Kimio Higashiyama, Tsuneji Nagai, Koichi Isowa

Journal:

International Journal of Pharmaceutics

Année:

2000

Langue:

english

Fichier:

PDF, 247 KB

english, 2000

21

The dose-related hypoglycemic effects of insulin emulsions incorporating highly purified EPA and DHA

Mariko Morishita, Masako Kajita, Atsuyuki Suzuki, Kozo Takayama, Yoshiyuki Chiba, Shingi Tokiwa, Tsuneji Nagai

Journal:

International Journal of Pharmaceutics

Année:

2000

Langue:

english

Fichier:

PDF, 189 KB

english, 2000

22

In vivo evaluation of doxorubicin carried with long circulating and remote loading proliposome

Wang Junping, Yoshie Maitani, Kozo Takayama, Tsuneji Nagai

Journal:

International Journal of Pharmaceutics

Année:

2000

Langue:

english

Fichier:

PDF, 136 KB

english, 2000

23

Pluronic® F-127 gels incorporating highly purified unsaturated fatty acids for buccal delivery of insulin

Mariko Morishita, Jose Mario Barichello, Kozo Takayama, Yoshiyuki Chiba, Shinji Tokiwa, Tsuneji Nagai

Journal:

International Journal of Pharmaceutics

Année:

2001

Langue:

english

Fichier:

PDF, 85 KB

english, 2001

24

Evaluation and structure–activity relationship of synthesized cyclohexanol derivatives on percutaneous absorption of ketoprofen using artificial neural network

Yasuko Obata, Chao Jie Li, Mikito Fujikawa, Kozo Takayama, Haruka Sato, Kimio Higashiyama, Koichi Isowa, Tsuneji Nagai

Journal:

International Journal of Pharmaceutics

Année:

2001

Langue:

english

Fichier:

PDF, 297 KB

english, 2001

25

Erratum to ‘In vivo evaluation of doxorubicin carried with long circulating and remote loading proliposome’ [Int. J. Pharm. 203(2000) 61–69]

Wang Junping, Yoshie Maitani, Kozo Takayama, Tsuneji Nagai

Journal:

International Journal of Pharmaceutics

Année:

2001

Langue:

english

Fichier:

PDF, 63 KB

english, 2001

26

The effects of water-soluble cyclodextrins on the histological integrity of the rat nasal mucosa

Kazunori Asai, Mariko Morishita, Hideo Katsuta, Shoji Hosoda, Katsuhiko Shinomiya, Masahiro Noro, Tsuneji Nagai, Kozo Takayama

Journal:

International Journal of Pharmaceutics

Année:

2002

Langue:

english

Fichier:

PDF, 916 KB

english, 2002

27

Pharmacokinetics and antitumor effects of vincristine carried by microemulsions composed of PEG-lipid, oleic acid, vitamin E and cholesterol

Wang Junping, Kozo Takayama, Tsuneji Nagai, Yoshie Maitani

Journal:

International Journal of Pharmaceutics

Année:

2003

Langue:

english

Fichier:

PDF, 177 KB

english, 2003

28

Preparation and pharmacokinetics of pirarubicin loaded dehydration–rehydration vesicles

Kumi Kawano, Kozo Takayama, Tsuneji Nagai, Yoshie Maitani

Journal:

International Journal of Pharmaceutics

Année:

2003

Langue:

english

Fichier:

PDF, 138 KB

english, 2003

29

In vitro and in vivo evaluation of mucoadhesive microspheres consisting of dextran derivatives and cellulose acetate butyrate

Yasunori Miyazaki, Kanako Ogihara, Shigeru Yakou, Tsuneji Nagai, Kozo Takayama

Journal:

International Journal of Pharmaceutics

Année:

2003

Langue:

english

Fichier:

PDF, 168 KB

english, 2003

30

Effect of 1-O-ethyl-3-butylcyclohexanol on the skin permeation of drugs with different physicochemical characteristics

Chao Jie Li, Yasuko Obata, Kimio Higashiyama, Tsuneji Nagai, Kozo Takayama

Journal:

International Journal of Pharmaceutics

Année:

2003

Langue:

english

Fichier:

PDF, 163 KB

english, 2003

31

An application of the computer optimization technique to wet granulation process involving explosive growth of particles

Yousuke Miyamoto, Shigeo Ogawa, Masaharu Miyajima, Masayuki Matsui, Hiroshi Sato, Kozo Takayama, Tsuneji Nagai

Journal:

International Journal of Pharmaceutics

Année:

1997

Langue:

english

Fichier:

PDF, 839 KB

english, 1997

32

Multi-objective simultaneous optimization based on artificial neural network in a ketoprofen hydrogel formula containing O-ethylmenthol as a percutaneous absorption enhancer

Junichi Takahara, Kozo Takayama, Koichi Isowa, Tsuneji Nagai

Journal:

International Journal of Pharmaceutics

Année:

1997

Langue:

english

Fichier:

PDF, 379 KB

english, 1997

33

Improving insulin enteral absorption using water-in-oil-in-water emulsion

Mariko Morishita, Ayako Matsuzawa, Kozo Takayama, Koichi Isowa, Tsuneji Nagai

Journal:

International Journal of Pharmaceutics

Année:

1998

Langue:

english

Fichier:

PDF, 386 KB

english, 1998

34

Buccal absorption through golden hamster cheek pouch in vitro and in vivo of 17β-estradiol from hydrogels containing three types of absorption enhancers

Manabu Kitano, Yoshie Maitani, Kozo Takayama, Tsuneji Nagai

Journal:

International Journal of Pharmaceutics

Année:

1998

Langue:

english

Fichier:

PDF, 1.25 MB

english, 1998

35

Effect of the cod-liver oil extract on the buccal permeation of ionized and nonionized forms of ergotamine using the keratinized epithelial-free membrane of hamster cheek pouch mucosa

Keiko Tsutsumi, Yasuko Obata, Kozo Takayama, Thorsteinn Loftsson, Tsuneji Nagai

Journal:

International Journal of Pharmaceutics

Année:

1998

Langue:

english

Fichier:

PDF, 97 KB

english, 1998

36

Permeation of several drugs through keratinized epithelial-free membrane of hamster cheek pouch

Keiko Tsutsumi, Yasuko Obata, Kozo Takayama, Koichi Isowa, Tsuneji Nagai

Journal:

International Journal of Pharmaceutics

Année:

1999

Langue:

english

Fichier:

PDF, 198 KB

english, 1999

37

Remote loading of diclofenac, insulin and fluorescein isothiocyanate labeled insulin into liposomes by pH and acetate gradient methods

SungHee Hwang, Yoshie Maitani, Xian-Rong Qi, Kozo Takayama, Tsuneji Nagai

Journal:

International Journal of Pharmaceutics

Année:

1999

Langue:

english

Fichier:

PDF, 146 KB

english, 1999

38

Enhanced rectal absorption of insulin-loaded Pluronic® F-127 gels containing unsaturated fatty acids

Jose Mario Barichello, Mariko Morishita, Kozo Takayama, Yoshiyuki Chiba, Shinji Tokiwa, Tsuneji Nagai

Journal:

International Journal of Pharmaceutics

Année:

1999

Langue:

english

Fichier:

PDF, 114 KB

english, 1999

39

Absorption of insulin from Pluronic F-127 gels following subcutaneous administration in rats

Jose Mario Barichello, Mariko Morishita, Kozo Takayama, Tsuneji Nagai

Journal:

International Journal of Pharmaceutics

Année:

1999

Langue:

english

Fichier:

PDF, 159 KB

english, 1999

40

Distribution characteristics of entrapped recombinant human erythropoietin in liposomes and its intestinal absorption in rats

Yoshie Maitani, Hidetaka Moriya, Naoto Shimoda, Kozo Takayama, Tsuneji Nagai

Journal:

International Journal of Pharmaceutics

Année:

1999

Langue:

english

Fichier:

PDF, 149 KB

english, 1999

41

The enhancing effect of soybean-derived sterylglucoside and β-sitosterol β-d-glucoside on nasal absorption in rabbits

Yoshie Maitani, Kouji Nakamura, Hiroshi Suenaga, Katsuo Kamata, Kozo Takayama, Tsuneji Nagai

Journal:

International Journal of Pharmaceutics

Année:

2000

Langue:

english

Fichier:

PDF, 146 KB

english, 2000

42

In vivo effects of highly purified docosahexaenoic acid on rectal insulin absorption

Yoshinori Onuki, Mariko Morishita, Kozo Takayama, Sinji Tokiwa, Yoshiyuki Chiba, Koichi Isowa, Tsuneji Nagai

Journal:

International Journal of Pharmaceutics

Année:

2000

Langue:

english

Fichier:

PDF, 306 KB

english, 2000

43

Fabrication of zirconium silicide intermetallic compounds with 16H-type crystal structure

Yukinori Ikarashi, Tamotsu Nagai, Kozo Ishizaki

Journal:

Materials Science and Engineering: A

Année:

1999

Langue:

english

Fichier:

PDF, 246 KB

english, 1999

44

Fatigue life estimation of adhesive bonded shaft joints

Makoto Imanaka, Waichiro Kishimoto, Kozo Okita, Hideaii Nakayama, Hiroyoshi Nagai

Journal:

International Journal of Fracture

Année:

1989

Langue:

english

Fichier:

PDF, 617 KB

english, 1989

45

The cloning of size-heterogeneous, Y-specific repetitive DNAs and their clinical application

Kozo Nagai, Isamu Yanagisawa, Ken Hayashi

Journal:

Molecular and Cellular Biochemistry

Année:

1991

Langue:

english

Fichier:

PDF, 793 KB

english, 1991

46

Peroxidase-positive acute leukemia with T-cell markers

Shinya Takagi, Ruriko Morita, Takayuki Monta, Soroku Yagihashi, Norihiko Shimoyama, Kazunori Nagai, Hiroyasu Kawabe, Mitsuaki Yoshida, Kozo Kurahashi, Masaaki Sano, Hiroshi Saito

Journal:

Annals of Hematology

Année:

1980

Langue:

english

Fichier:

PDF, 213 KB

english, 1980

47

Molecular basis governing primary sex in mammals

Journal:

Journal of Human Genetics

Année:

1996

Langue:

english

Fichier:

PDF, 1.08 MB

english, 1996

48

The characterization of human male-specific 5.7 kb DNA(pKY-1) and its application to fetal sex-determination probe

Kozo Nagai, Satoru Koike, Ryo Kominami, Masami Muramatsu, Yutaka Nakahori, Yasuo Nakagome, Hiroaki Soma, Isamu Yanagisawa

Journal:

Journal of Human Genetics

Année:

1989

Langue:

english

Fichier:

PDF, 674 KB

english, 1989

49

Comparison of penetration-enhancing ability of laurocapram, N-methyl-2-pyrrolidone and dodecyl-L-pyroglutamate

Jan Příborský, Kozo Takayama, Tsuneji Nagai, Danuše Waitzová, Jiří Elis, Yuji Makino, Yoshiki Suzuki

Journal:

International Journal of Clinical Pharmacy

Année:

1988

Langue:

english

Fichier:

PDF, 353 KB

english, 1988

50

Intestinal cryptosporidiosis as an initial manifestation in a previously healthy Japanese patient with AIDS

Hirotoshi Fujikawa, Hiroshi Miyakawa, Kanae Iguchi, Mika Nishizawa, Kunihiko Moro, Kozo Nagai, Miyuki Ishibashi

Journal:

Journal of Gastroenterology

Année:

2002

Langue:

english

Fichier:

PDF, 1.19 MB

english, 2002